Generation of tumor-specific cytotoxic T lymphocytes and memory T cells by immunization with tumor-derived heat shock protein gp96

被引:52
作者
Janetzki, S [1 ]
Blachere, NE [1 ]
Srivastava, PK [1 ]
机构
[1] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA
来源
JOURNAL OF IMMUNOTHERAPY | 1998年 / 21卷 / 04期
关键词
antigens; peptides; chaperones; immunomodulators;
D O I
10.1097/00002371-199807000-00004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumor-derived heat shock proteins have been shown previously to elicit specific prophylactic immunity to cognate tumors. Here we establish that administration of gp96 results in generation of tumor-specific cytotoxic T lymphocyte response in addition to protective immunity. In one instance, gp96 preparations are shown to elicit an immune response against a tumor; where intact tumor cells are unable to do so. Finally, our results indicate that gp96 preparations elicit a memory T cell response that is capable of being recalled.
引用
收藏
页码:269 / 276
页数:8
相关论文
共 44 条
[1]   AFFINITY PANNING OF A LIBRARY OF PEPTIDES DISPLAYED ON BACTERIOPHAGES REVEALS THE BINDING-SPECIFICITY OF BIP [J].
BLONDELGUINDI, S ;
CWIRLA, SE ;
DOWER, WJ ;
LIPSHUTZ, RJ ;
SPRANG, SR ;
SAMBROOK, JF ;
GETHING, MJH .
CELL, 1993, 75 (04) :717-728
[2]   THERAPY WITH MONOCLONAL-ANTIBODIES BY ELIMINATION OF T-CELL SUBSETS INVIVO [J].
COBBOLD, SP ;
JAYASURIYA, A ;
NASH, A ;
PROSPERO, TD ;
WALDMANN, H .
NATURE, 1984, 312 (5994) :548-551
[3]   SELECTIVE RADIATION-RESISTANCE OF IMMUNOLOGICALLY INDUCED T-CELLS AS THE BASIS FOR IRRADIATION-INDUCED T-CELL-MEDIATED REGRESSION OF IMMUNOGENIC TUMOR [J].
DUNN, PL ;
NORTH, RJ .
JOURNAL OF LEUKOCYTE BIOLOGY, 1991, 49 (04) :388-396
[4]  
EBERT EC, 1987, J IMMUNOL, V138, P2161
[5]   MOLECULAR HETEROGENEITY OF TUMOR REJECTION ANTIGEN HEAT-SHOCK PROTEIN GP96 [J].
FELDWEG, AM ;
SRIVASTAVA, PK .
INTERNATIONAL JOURNAL OF CANCER, 1995, 63 (02) :310-314
[6]   PEPTIDE-BINDING SPECIFICITY OF THE MOLECULAR CHAPERONE BIP [J].
FLYNN, GC ;
POHL, J ;
FLOCCO, MT ;
ROTHMAN, JE .
NATURE, 1991, 353 (6346) :726-730
[7]   A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene [J].
Guilloux, Y ;
Lucas, S ;
Brichard, VG ;
VanPel, A ;
Viret, C ;
DePlaen, E ;
Brasseur, F ;
Lethe, B ;
Jotereau, F ;
Boon, T .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (03) :1173-1183
[8]   CANCER ANTIGENS - IMMUNE RECOGNITION OF SELF AND ALTERED SELF [J].
HOUGHTON, AN .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :1-4
[9]  
HUBER D, 1992, J IMMUNOL, V148, P277
[10]  
JAFFEE EM, 1995, SEMIN ONCOL, V22, P81