Evidence for three-dimensional interlayer correlations in cationic lipid-DNA complexes as observed by cryo-electron microscopy

被引：71

作者：

Battersby, BJ

Grimm, R

Huebner, S

Cevc, G

机构：

[1] Tech Univ Munchen, Klinikum Rechts Isar, D-81675 Munich, Germany

[2] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1998年 / 1372卷 / 02期

关键词：

lipid-DNA complex; cryo transmission electron microscopy; DNA; cationic liposome; correlation force;

D O I：

10.1016/S0005-2736(98)00062-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A fingerprint-like pattern across multilamellar, lipid-DNA complexes is attributed to DNA condensed as parallel helices between lipid bilayers. It is argued that the patterning indicates the existence of 3-D correlation forces between DNA-covered bilayers, following the DNA-driven formation of multilamellar liposomes from unilamellar vesicles. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：379 / 383

页数：5

共 12 条

[1]

DeJong AF, 1996, PROG BIOPHYS MOL BIO, V65, pPH116

[2] Two-dimensional condensation of DNA molecules on cationic lipid membranes [J].