Second AKT: The rise of SGK in cancer signalling

被引：127

作者：

Bruhn, Maressa A. ^{[1
,4
]}

Pearson, Richard B. ^{[1
,2
,3
]}

Hannan, Ross D. ^{[1
,2
,3
]}

Sheppard, Karen E. ^{[1
,2
]}

机构：

[1] Peter MacCallum Canc Ctr, Growth Control & Differentiat Program, Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[4] Flinders Univ S Australia, Sch Biol Sci, Bedford Pk, SA 5042, Australia

来源：

GROWTH FACTORS | 2010年 / 28卷 / 06期

关键词：

SGK; AKT; PI3Kinase; mTOR; cancer; GLUCOCORTICOID-INDUCIBLE KINASE; INDUCED PROTEIN-KINASE; FORKHEAD TRANSCRIPTION FACTOR; STIMULATES PROMOTER ACTIVITY; MAMMARY EPITHELIAL-CELLS; GROWTH-FACTOR RECEPTOR; PHOX HOMOLOGY DOMAIN; KAPPA-B KINASE; REGULATED KINASE; BREAST-CANCER;

D O I：

10.3109/08977194.2010.518616

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The serum and glucocorticoid kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK-1, SGK-2 and SGK-3 This family of kinases is highly homologous to the AKT kinase family, sharing similar upstream activators and downstream targets SGKs have been implicated in the regulation of cell growth, proliferation, survival and migration cellular processes that are dysregulated in cancer Furthermore, SGKs lie downstream of phosphoinositide-3-kinase (PI3Kinase) signalling and interact at various levels with RAS/RAF/ERK signalling, two pathways that are involved in promoting tumorigenesis Recent evidence suggests that mutant PI3Kinase can induce tumorigenesis through an AKT-independent but SGK3-dependent mechanism, thus implicating SGKs as potential players in malignant transformation Here, we will review the current state of knowledge on the regulation of the SGKs and their role in normal cell physiology and transformation with a particular focus on SGK3

引用

收藏

页码：394 / 408

页数：15

相关论文

共 133 条

[1] Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: A functional role for the spl family in promoter activity [J].

Alliston, TN ;

Maiyar, AC ;

Buse, P ;

Firestone, GL ;

Richards, JS .

MOLECULAR ENDOCRINOLOGY, 1997, 11 (13) :1934-1949

[2] Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle [J].

Alonso, L ;

Okada, H ;

Pasolli, HA ;

Wakeham, A ;

You- Ten, AI ;

Mak, TW ;

Fuchs, E .

JOURNAL OF CELL BIOLOGY, 2005, 170 (04) :559-570

[3] Perturbations of the AKT signaling pathway in human cancer [J].

Altomare, DA ;

Testa, JR .

ONCOGENE, 2005, 24 (50) :7455-7464

[4] Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation [J].

Amato, Rosario ;

D'Antona, Lucia ;

Porciatti, Giovanni ;

Agosti, Valter ;

Menniti, Miranda ;

Rinaldo, Cinzia ;

Costa, Nicola ;

Bellacchio, Emanuele ;

Mattarocci, Stefano ;

Fuiano, Giorgio ;

Soddu, Silvia ;

Paggi, Marco G. ;

Lang, Florian ;

Perrotti, Nicola .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2009, 87 (12) :1221-1239

[5] Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response [J].

Aoyama, T ;

Matsui, T ;

Novikov, M ;

Park, J ;

Hemmings, B ;

Rosenzweig, A .

CIRCULATION, 2005, 111 (13) :1652-1659

[6] Regulation of ceramide biosynthesis by TOR complex 2 [J].

Aronova, Sofia ;

Wedaman, Karen ;

Aronov, Pavel A. ;

Fontes, Kristin ;

Ramos, Karmela ;

Hammock, Bruce D. ;

Powers, Ted .

CELL METABOLISM, 2008, 7 (02) :148-158

[7] Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1 [J].

Arteaga, Maria Francisca ;

de la Rosa, Diego Alvarez ;

Alvarez, Jose A. ;

Canessa, Cecilia M. .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (06) :2072-2080

[8] An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery [J].

Arteaga, Maria Francisca ;

Wang, Lin ;

Ravid, Tommer ;

Hochstrasser, Mark ;

Canessa, Cecilia M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11178-11183

[9] Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 [J].

Baldwin, Amy ;

Grueneberg, Dorre A. ;

Hellner, Karin ;

Sawyer, Jacqueline ;

Grace, Miranda ;

Li, Wenliang ;

Harlow, Ed ;

Munger, Karl .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (28) :12463-12468

[10] The serum- and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling -: Role in redox-sensitive regulation of tissue factor by thrombin [J].

BelAiba, RS ;

Djordjevic, T ;

Bonello, S ;

Artunc, F ;

Lang, F ;

Hess, J ;

Görlach, A .

CIRCULATION RESEARCH, 2006, 98 (06) :828-836

← 1 2 3 4 5 6 7 8 9 10 →