Prostaglandins in macula densa function

被引：28

作者：

Harris, RC

Wang, JL

Cheng, HF

Zhang, MZ

McKanna, JA

机构：

[1] Vanderbilt Univ, Dept Med, Sch Med, Div Nephrol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Cell Biol, Sch Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, George M OBrien Kidney & Urol Dis Ctr, Nashville, TN 37212 USA

来源：

KIDNEY INTERNATIONAL | 1998年 / 54卷

关键词：

eicosanoids; glomerular hemodynamics; prostaglandins; cyclooxygenase; renin; nephrogenesis;

D O I：

10.1046/j.1523-1755.1998.06710.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclooxygenase (COX)-2 mRNA and immunoreactive protein localize to the macula densa and adjacent cortical thick ascending limb in renal cortex, and chronic NaCl restriction increases expression of this enzyme. These findings suggest an integral role for eicosanoids generated by macula densa-associated COX-2 in mediating renin release. As selective inhibitors of COX-2 become available, it will be important to assess their effects on the renin-angiotensin system and glomerular hemodynamics.

引用

页码：S49 / S52

页数：4

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