Management of Postmenopausal Osteoporosis

被引：59

作者：

Andreopoulou, Panagiota ^{[1
]}

Bockman, Richard S. ^{[1
,2
]}

机构：

[1] Hosp Special Surg, Endocrine Serv, Dept Med, New York, NY 10021 USA

[2] Weill Cornell Med Coll, New York, NY 10065 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 66 | 2015年 / 66卷

关键词：

bone microarchitecture; fracture risk; combination therapy; BONE-MINERAL DENSITY; VITAMIN-D SUPPLEMENTATION; PARATHYROID-HORMONE; 1-84; VERTEBRAL FRACTURE RISK; YEARLY ZOLEDRONIC ACID; HIP FRACTURE; NONVERTEBRAL FRACTURES; CAUCASIAN WOMEN; SPINE BMD; SCORE TBS;

D O I：

10.1146/annurev-med-070313-022841

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

A hallmark of menopause, which follows the decline in the ovarian production of estrogen, is the aggressive and persistent loss of bone mineral and structural elements leading to loss of bone strength and increased fracture risk. This review focuses on newer methods of diagnosing osteoporosis and assessing fracture risk, as well as on novel management strategies for prevention and treatment. Fracture-risk prediction has been significantly enhanced by the development of methods such as the trabecular bone score, which helps assess bone microarchitecture and adds value to standard bone densitometry, and the Fracture Risk Assessment Tool (FRAX) algorithm techniques. The treatment of osteoporosis, which has the goals of fracture prevention and risk reduction, is moving beyond traditional monotherapies with antiresorptives and anabolic agents into new combination regimens.

引用

页码：329 / 342

页数：14

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