Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response

被引：56

作者：

Li, JCB ^{[1
]}

Lee, DCW ^{[1
]}

Cheung, BKW ^{[1
]}

Lau, ASY ^{[1
]}

机构：

[1] Univ Hong Kong, Fac Med, Dept Paediat & Adolescent Med, Immunol Res Lab, Hong Kong, Hong Kong, Peoples R China

来源：

FEBS LETTERS | 2005年 / 579卷 / 14期

关键词：

HIV-1; HIV tat protein; protein kinase PKR; cytokines; transcription factors;

D O I：

10.1016/j.febslet.2005.04.060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3055 / 3062

页数：8

共 30 条

[1] The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR [J].