Cytokinesis in trypanosomatilds

被引：50

作者：

Hammarton, Tansy C.

Monnerat, Severine

Mottram, Jeremy C.

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Wellcome Ctr Mol Parasitol, Glasgow G12 8TA, Lanark, Scotland

[2] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8TA, Lanark, Scotland

来源：

CURRENT OPINION IN MICROBIOLOGY | 2007年 / 10卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.mib.2007.10.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The process of cytokinesis, where the cytoplasm of one cell is divided to produce two daughter cells, is intricate in trypanosomatids because of the requirement to replicate and segregate a number of single copy organelles, including the nucleus, kinetoplast, Golgi apparatus, and flagellum. Identifying regulators of the three stages of cytokinesis, initiation, furrow ingression, and abscission is complicated by the fact that cell division in trypanosomatids is easily perturbed and aberrant cells are readily produced during functional characterization of gene products. In this review, we discuss direct and indirect effects on cytokinesis, using Trypanosoma brucei as a model.

引用

页码：520 / 527

页数：8

共 58 条

[1]

AMBIT A, 2007, IN PRESS CELL DEATH

[2] Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella [J].

Baron, Desiree M. ;

Ralston, Katherine S. ;

Kabututu, Zakayi P. ;

Hill, Kent L. .

JOURNAL OF CELL SCIENCE, 2007, 120 (03) :478-491

[3]

Bastin P, 2000, J CELL SCI, V113, P3321

[4] TAXOL, A MICROTUBULE STABILIZING AGENT, BLOCKS THE REPLICATION OF TRYPANOSOMA-CRUZI [J].

BAUM, SG ;

WITTNER, M ;

NADLER, JP ;

HORWITZ, SB ;

DENNIS, JE ;

SCHIFF, PB ;

TANOWITZ, HB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4571-4575

[5] The genome of the African trypanosome Trypanosoma brucei [J].

Berriman, M ;

Ghedin, E ;

Hertz-Fowler, C ;

Blandin, G ;

Renauld, H ;

Bartholomeu, DC ;

Lennard, NJ ;

Caler, E ;

Hamlin, NE ;

Haas, B ;

Böhme, W ;

Hannick, L ;

Aslett, MA ;

Shallom, J ;

Marcello, L ;

Hou, LH ;

Wickstead, B ;

Alsmark, UCM ;

Arrowsmith, C ;

Atkin, RJ ;

Barron, AJ ;

Bringaud, F ;

Brooks, K ;

Carrington, M ;

Cherevach, I ;

Chillingworth, TJ ;

Churcher, C ;

Clark, LN ;

Corton, CH ;

Cronin, A ;

Davies, RM ;

Doggett, J ;

Djikeng, A ;

Feldblyum, T ;

Field, MC ;

Fraser, A ;

Goodhead, I ;

Hance, Z ;

Harper, D ;

Harris, BR ;

Hauser, H ;

Hostetter, J ;

Ivens, A ;

Jagels, K ;

Johnson, D ;

Johnson, J ;

Jones, K ;

Kerhornou, AX ;

Koo, H ;

Larke, N .

SCIENCE, 2005, 309 (5733) :416-422

[6] Conserved and specific functions of axoneme components in trypanosome motility [J].

Branche, Carole ;

Kohl, Linda ;

Toutirais, Geraldine ;

Buisson, Johanna ;

Cosson, Jacky ;

Bastin, Philippe .

JOURNAL OF CELL SCIENCE, 2006, 119 (16) :3443-3455

[7] Flagellar motility is required for the viability of the bloodstream trypanosome [J].

Broadhead, R ;

Dawe, HR ;

Farr, H ;

Griffiths, S ;

Hart, SR ;

Portman, N ;

Shaw, MK ;

Ginger, ML ;

Gaskell, SJ ;

McKean, PG ;

Gull, K .

NATURE, 2006, 440 (7081) :224-227

[8] Ablation of the single dynamin of T-brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest [J].

Chanez, Anne-Laure ;

Hehl, Adrian B. ;

Engstler, Markus ;

Schneider, Andre .

JOURNAL OF CELL SCIENCE, 2006, 119 (14) :2968-2974

[9] CELL CYCLE IN CRITHIDIA-FASCICULATA - TEMPORAL RELATIONSHIPS BETWEEN SYNTHESIS OF DEOXYRIBONUCLEIC ACID IN NUCLEUS AND IN KINETOPLAST [J].

COSGROVE, WB ;

SKEEN, MJ .

JOURNAL OF PROTOZOOLOGY, 1970, 17 (02) :172-&

[10]

DAS A, 1994, J CELL SCI, V107, P3477

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