SOCS1 in cancer: An oncogene and a tumor suppressor

被引：58

作者：

Beaurivage, Claudia ^{[1
]}

Champagne, Audrey ^{[1
]}

Tobelaim, William S. ^{[1
]}

Pomerleau, Veronique ^{[1
]}

Menendez, Alfredo ^{[2
]}

Saucier, Caroline ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Anat & Cell Biol, Sherbrooke, PQ J1K 2R1, Canada

[2] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Microbiol & Infect Dis, Sherbrooke, PQ J1K 2R1, Canada

来源：

CYTOKINE | 2016年 / 82卷

基金：

加拿大健康研究院;

关键词：

SOCS1; Cytokine; Cancer; Tumor suppressor; Oncogene; Colorectal cancer; ISLAND METHYLATOR PHENOTYPE; HUMAN HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; ANTITUMOR-ACTIVITY; CYTOKINE SIGNALING-1; GENE-EXPRESSION; ABERRANT METHYLATION; LIVER-REGENERATION; MET RECEPTOR; P53;

D O I：

10.1016/j.cyto.2016.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.

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收藏

页码：87 / 94

页数：8

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