Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride

被引：152

作者：

Imamoto, T ^{[1
]}

Kikuchi, S ^{[1
]}

Miura, T ^{[1
]}

Wada, Y ^{[1
]}

机构：

[1] Chiba Univ, Fac Sci, Dept Chem, Inage Ku, Chiba 2638522, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 01期

关键词：

D O I：

10.1021/ol0068041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.

引用

页码：87 / 90

页数：4

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