Mechanisms of immunomodulation by mesenchymal stem cells

被引：35

作者：

Ozaki, Katsutoshi ^{[1
]}

Sato, Kazuya ^{[1
]}

Oh, Iekuni ^{[1
]}

Meguro, Akiko ^{[1
]}

Tatara, Raine ^{[1
]}

Muroi, Kazuo ^{[1
]}

Ozawa, Keiya ^{[1
]}

机构：

[1] Jichi Med Univ, Dept Med, Div Hematol, Shimotsuke, Tochigi 3290498, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 01期

关键词：

mesenchymal stem cells; immunomodulation; GVHD;

D O I：

10.1532/IJH97.07003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stem cells (MSCs) have been identified in animals, especially in bone marrow. As stem cells, they have the ability to differentiate into multiple cell types. This potential raises exciting therapeutic possibilities. A recent report described the successful use of MSCs for the treatment of graft-versus-host disease; however, the scientific community has yet to define the molecular mechanisms of immunomodulation by MSCs. This review summarizes what is known and discusses the conflicting data with regard to the mechanisms of immunomodulation by MSCs.

引用

页码：5 / 7

页数：3

共 20 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2] Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness [J].

Beyth, S ;

Borovsky, Z ;

Mevorach, D ;

Liebergall, M ;

Gazit, Z ;

Aslan, H ;

Galun, E ;

Rachmilewitz, J .

BLOOD, 2005, 105 (05) :2214-2219

[3] Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli [J].

Di Nicola, M ;

Carlo-Stella, C ;

Magni, M ;

Milanesi, M ;

Longoni, PD ;

Matteucci, P ;

Grisanti, S ;

Gianni, AM .

BLOOD, 2002, 99 (10) :3838-3843

[4] Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals [J].

Djouad, F ;

Plence, P ;

Bony, C ;

Tropel, P ;

Apparailly, F ;

Sany, J ;

Noël, D ;

Jorgensen, C .

BLOOD, 2003, 102 (10) :3837-3844

[5] Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement [J].

Dominici, M. ;

Le Blanc, K. ;

Mueller, I. ;

Slaper-Cortenbach, I. ;

Marini, F. C. ;

Krause, D. S. ;

Deans, R. J. ;

Keating, A. ;

Prockop, D. J. ;

Horwitz, E. M. .

CYTOTHERAPY, 2006, 8 (04) :315-317

[6] Bone marrow mesenchymal stem cefls induce division arrest anergy of activated T cells [J].

Glennie, S ;

Soeiro, I ;

Dyson, PJ ;

Lam, EWF ;

Dazzi, F .

BLOOD, 2005, 105 (07) :2821-2827

[7] Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone [J].

Horwitz, EM ;

Gordon, PL ;

Koo, WKK ;

Marx, JC ;

Neel, MD ;

McNall, RY ;

Muul, L ;

Hofmann, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) :8932-8937

[8] Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2 [J].

Kim, SF ;

Huri, DA ;

Snyder, SH .

SCIENCE, 2005, 310 (5756) :1966-1970

[9] Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide [J].

Krampera, M ;

Glennie, S ;

Dyson, J ;

Scott, D ;

Laylor, R ;

Simpson, E ;

Dazzi, F .

BLOOD, 2003, 101 (09) :3722-3729

[10] Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients [J].

Lazarus, HM ;

Koc, ON ;

Devine, SM ;

Curtin, P ;

Maziarz, RT ;

Holland, HK ;

Shpall, EJ ;

McCarthy, P ;

Atkinson, K ;

Cooper, BW ;

Gerson, SL ;

Laughlin, MJ ;

Loberiza, FR ;

Moseley, AB ;

Bacigalupo, A .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (05) :389-398

← 1 2 →