Seasonal changes in bone metabolism in sheep

被引：36

作者：

Arens, Daniel ^{[1
]}

Sigrist, Ilonka ^{[1
]}

Alini, Mauro ^{[1
]}

Schawalder, Peter ^{[3
]}

Schneider, Erich ^{[1
]}

Egermann, Marcus ^{[1
,2
,3
]}

机构：

[1] AO Res Inst, CH-7270 Davos, Switzerland

[2] Univ Heidelberg, Dept Orthoped Surg, D-6900 Heidelberg, Germany

[3] Univ Bern, Dept Small Anim Surg, CH-3012 Bern, Switzerland

来源：

VETERINARY JOURNAL | 2007年 / 174卷 / 03期

关键词：

bone mineral density; osteoporosis; seasonal changes; animal model; sheep;

D O I：

10.1016/j.tvjl.2006.10.001

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 [兽医学];

摘要：

There is a great need for animal models of osteoporosis and sheep are a suitable large animal that meets most requirements. Since it is known that bone mass in humans responds to seasonal changes, this study investigated natural bone metabolism in sheep in order to better define the sheep as a model for osteoporosis. Bone mineral density (BMD), trabecular structure, biochemical markers of bone formation and resorption and estrogen were analysed over a period of 18 months. The lowest BMDs, measured by peripheral quantitative computed tomography (pQCT), were observed during winter. Thereafter, a 5.1% increase in BNID was observed during spring and summer (P < 0.05). Bone resorption markers showed a variable pattern, with higher values in spring compared to autumn (P < 0.001). The physiological estrus phase during autumn was detected by serum estrogen levels. The findings show that it is necessary to take seasonal variations into account if sheep are used to establish an animal model for osteoporosis. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：585 / 591

页数：7

共 35 条

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