Preparation and biocompatibility of electrospun poly(L-lactide-co-ε-caprolactone)/fibrinogen blended nanofibrous scaffolds

被引：34

作者：

Fang, Zhengdong ^{[1
]}

Fu, Weiguo ^{[1
]}

Dong, Zhihui ^{[1
]}

Zhang, Xiangman ^{[1
]}

Gao, Bin ^{[1
]}

Guo, Daqiao ^{[1
]}

He, Hongbing ^{[1
]}

Wang, Yuqi ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Shanghai 200032, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2011年 / 257卷 / 09期

基金：

国家高技术研究发展计划(863计划);

关键词：

Electrospinning; Tissue engineering; Nanofibrous scaffold; Natural polymer; Synthetic polymer; DIAMETER BLOOD-VESSELS; EXTRACELLULAR-MATRIX; TISSUE; CELL; FIBRINOGEN; MORPHOLOGY; FIBERS; PROLIFERATION; CHONDROCYTES; FABRICATION;

D O I：

10.1016/j.apsusc.2010.12.011

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Electrospun blended nanofibrous scaffolds were fabricated from an synthetic biodegradable polymer (poly(L-lactide-co-epsilon-caprolactone): PLCL; 8% solution) and a natural protein (fibrinogen; 100 mg/ml solution) with different volume ratios. Results showed that the blended scaffolds consisted of nanoscale fibers with mean diameters ranging from 224 to 450 nm. The deposition of the fibrinogen amino groups on the surfaces of the blended scaffolds was confirmed by XPS. The hydrophilicity of the blended scaffolds were improved with the fibrinogen content increasing in the blended system. Cell viability assay and SEM results showed that human umbilical vein endothelial cells (HUVECs) had progressive growth and well spread morphology on the blended scaffolds. This study demonstrated that electrospun PLCL/fibrinogen blended scaffolds have potential application in tissue engineering. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：4133 / 4138

页数：6

共 31 条

[1]

Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering [J].