The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis

被引：70

作者：

Frisullo, Giovanni ^{[1
]}

Mirabella, Massimiliano ^{[1
]}

Angelucci, Francesco ^{[2
]}

Caggiula, Marcella ^{[2
]}

Morosetti, Roberta ^{[1
]}

Sancricca, Cristina ^{[1
]}

Patanella, Agata Katia ^{[1
]}

Nociti, Viviana ^{[1
,2
]}

Lorio, Raffaele ^{[1
]}

Bianco, Assunta ^{[1
]}

Tomassini, Valentina ^{[3
]}

Pozzilli, Carlo ^{[3
]}

Tonali, Pietro Attilio ^{[1
]}

Matarese, Giuseppe ^{[4
]}

Batocchi, Anna Paola ^{[1
]}

机构：

[1] Univ Canol Sacro Cuore, Dipartimento Neurosci, Ist Neurol, I-00168 Rome, Italy

[2] Fdn Don C Gnocchi, Rome, Italy

[3] Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy

[4] Ist Endocrinol & Oncol Sperimentale, I-80131 Naples, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 192卷 / 1-2期

关键词：

leptin; transcription factors; SOCS3; STAT3; multiple sclerosis;

D O I：

10.1016/j.jneuroim.2007.08.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：174 / 183

页数：10

共 38 条

[1] Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta [J].

Batocchi, AP ;

Rotondi, M ;

Caggiula, M ;

Frisullo, G ;

Odoardi, F ;

Nociti, V ;

Carella, C ;

Tonali, PA ;

Mirabella, M .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 139 (1-2) :150-154

[2] The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].

Baumann, H ;

Morella, KK ;

White, DW ;

Dembski, M ;

Bailon, PS ;

Kim, HK ;

Lai, CF ;

Tartaglia, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378

[3] Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis [J].

Busso, N ;

So, A ;

Chobaz-Péclat, V ;

Morard, C ;

Martinez-Soria, E ;

Talabot-Ayer, D ;

Gabay, C .

JOURNAL OF IMMUNOLOGY, 2002, 168 (02) :875-882

[4] Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: Evidence for an IL-10-induced pathway that is independent of STAT protein activation [J].

Cassatella, MA ;

Gasperini, S ;

Bovolenta, C ;

Calzetti, F ;

Vollebregt, M ;

Scapini, P ;

Marchi, M ;

Suzuki, R ;

Suzuki, A ;

Yoshimura, A .

BLOOD, 1999, 94 (08) :2880-2889

[5] Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) - In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients [J].

Chatzantoni, K ;

Papathanassopoulos, P ;

Gourzoulidou, E ;

Mouzaki, A .

JOURNAL OF AUTOIMMUNITY, 2004, 23 (02) :169-177

[6] Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity:: Role of tumor necrosis factor α and IL-18 [J].

Faggioni, R ;

Jones-Carson, J ;

Reed, DA ;

Dinarello, CA ;

Feingold, KR ;

Grunfeld, C ;

Fantuzzi, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (05) :2367-2372

[7]

Fantuzzi G, 2000, J LEUKOCYTE BIOL, V68, P437

[8]

FATELI M, 2006, J IMMUNOL METHODS, V312, P190

[9] Leptin enhances the release of cytokines by peripheral blood mononuclear cells from relapsing multiple sclerosis patients [J].

Frisullo, G ;

Angelucci, F ;

Mirabella, M ;

Caggiula, M ;

Patanella, K ;

Nociti, V ;

Tonali, PA ;

Batocchi, AP .

JOURNAL OF CLINICAL IMMUNOLOGY, 2004, 24 (03) :287-293

[10] pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity [J].

Frisullo, Giovanni ;

Angelucci, Francesco ;

Caggiula, Marcella ;

Nociti, Viviana ;

Iorio, Raffaele ;

Patanella, Agata Katia ;

Sancricca, Cristina ;

Mirabella, Massimiliano ;

Tonali, Pietro Attilio ;

Batocchi, Anna Paola .

JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (05) :1027-1036

← 1 2 3 4 →