From the molecule to the clinic - inhibiting HER2 to treat breast cancer.

被引:49
作者
Eisenhauer, EA [1 ]
机构
[1] Queens Univ, Kingston, ON K7L 3N6, Canada
关键词
D O I
10.1056/NEJM200103153441110
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:841 / 842
页数:2
相关论文
共 14 条
[1]   HUMANIZATION OF AN ANTI-P185HER2 ANTIBODY FOR HUMAN CANCER-THERAPY [J].
CARTER, P ;
PRESTA, L ;
GORMAN, CM ;
RIDGWAY, JBB ;
HENNER, D ;
WONG, WLT ;
ROWLAND, AM ;
KOTTS, C ;
CARVER, ME ;
SHEPARD, HM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4285-4289
[2]   Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease [J].
Cobleigh, MA ;
Vogel, CL ;
Tripathy, D ;
Robert, NJ ;
Scholl, S ;
Fehrenbacher, L ;
Wolter, JM ;
Paton, V ;
Shak, S ;
Lieberman, G ;
Slamon, DJ .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (09) :2639-2648
[3]   INCREASED EXPRESSION OF THE PUTATIVE GROWTH-FACTOR RECEPTOR P185HER2 CAUSES TRANSFORMATION AND TUMORIGENESIS OF NIH-3T3 CELLS [J].
HUDZIAK, RM ;
SCHLESSINGER, J ;
ULLRICH, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7159-7163
[4]   HER-2/neu analysis in archival tissue samples of human breast cancer:: Comparison of immunohistochemistry and fluorescence in situ hybridization [J].
Lebeau, A ;
Deimling, D ;
Kaltz, C ;
Sendelhofert, A ;
Iff, A ;
Luthardt, B ;
Untch, M ;
Löhrs, U .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (02) :354-363
[5]  
*ONC DRUGS ADV COM, 1998, ONC DRUGS ADV COMM 5
[6]   erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer [J].
Paik, SM ;
Bryant, J ;
Park, CH ;
Fisher, B ;
Tan-Chiu, E ;
Hyams, D ;
Fisher, ER ;
Lippman, ME ;
Wickerham, DL ;
Wolmark, N .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (18) :1361-1370
[7]   Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers [J].
Pegram, M ;
Hsu, S ;
Lewis, G ;
Pietras, R ;
Beryt, M ;
Sliwkowski, M ;
Coombs, D ;
Baly, D ;
Kabbinavar, F ;
Slamon, D .
ONCOGENE, 1999, 18 (13) :2241-2251
[8]   Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs [J].
Pietras, RJ ;
Pegram, MD ;
Finn, RS ;
Maneval, DA ;
Slamon, DJ .
ONCOGENE, 1998, 17 (17) :2235-2249
[9]  
Ryan PD, 2000, CLIN CANCER RES, V6, P4607
[10]   Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. [J].
Slamon, DJ ;
Leyland-Jones, B ;
Shak, S ;
Fuchs, H ;
Paton, V ;
Bajamonde, A ;
Fleming, T ;
Eiermann, W ;
Wolter, J ;
Pegram, M ;
Baselga, J ;
Norton, L .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (11) :783-792