The fibroblast: growth factor-2 is not essential for melanoma formation in a transgenic mouse model

被引：6

作者：

Ackermann, J ^{[1
]}

Beermann, F ^{[1
]}

机构：

[1] Swiss Inst Expt Canc Res, NCCR, CH-1066 Epalinges, Switzerland

来源：

PIGMENT CELL RESEARCH | 2005年 / 18卷 / 04期

关键词：

FGF2; N-ras; knockout; transgenic; melanocyte; tyrosinase;

D O I：

10.1111/j.1600-0749.2005.00243.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibroblast growth factor 2 (FGF2) has been assigned a role in melanocyte proliferation and in development of human cutaneous melanoma. We have used a transgenic mouse melanoma model in combination with mice lacking mouse FGF2 to analyse the possible implication of FGF2 in melanomagenesis. Tyr::N-ras(Q61K) transgenic mice which are deficient for FGF2 and the tumor suppressors p16(INK4a) and p19(ARF) are hyperpigmented and develop cutaneous metastasizing melanoma, with no difference to mice wildtype for FGF2. We conclude from our data, that FGF2 is not essential for melanoma progression and metastasis.

引用

页码：315 / 319

页数：5

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