Coupling of the antennapedia third helix to a potent antagonist of the p53/hdm2 protein-protein interaction

被引：12

作者：

García-Echeverría, C ^{[1
]}

Furet, P ^{[1
]}

Chène, P ^{[1
]}

机构：

[1] Novartis Pharma Inc, Oncol Res, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(01)00394-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The use of cell-membrane translocating sequences for intracellular delivery of peptides can be a powerful approach to validate drug discovery targets in cellular settings. To accomplish this, a protocol has been implemented to couple the antennapedia third helix (residues 43-58) to a potent antagonist of the p53/hdm2 protein-protein interaction without affecting its in vitro inhibitory activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2161 / 2164

页数：4

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