The cyclophilins

被引：528

作者：

Wang, P ^{[1
]}

Heitman, J

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Childrens Hosp, Res Inst Children, New Orleans, LA 70118 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, New Orleans, LA 70118 USA

[3] Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70118 USA

[4] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[6] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[7] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 07期

关键词：

D O I：

10.1186/gb-2005-6-7-226

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyclophilins ( Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are collectively known as immunophilins and also include the FK-506-binding proteins and the parvulins. Cyclophilins are found in all cells of all organisms studied, in both prokaryotes and eukaryotes; humans have a total of 16 cyclophilin proteins, Arabidopsis up to 29 and Saccharomyces 8. The first member of the cyclophilins to be identified in mammals, cyclophilin A, is the major cellular target for, and thus mediates the actions of, the immunosuppressive drug cyclosporin A. Cyclophilin A forms a ternary complex with cyclosporin A and the calcium-calmodulin-activated serine/threonine-specific protein phosphatase calcineurin; formation of this complex prevents calcineurin from regulating cytokine gene transcription. Recent studies have implicated a diverse array of additional cellular functions for cyclophilins, including roles as chaperones and in cell signaling.

引用

页数：6

共 73 条

[1] A CYCLOPHILIN-RELATED PROTEIN INVOLVED IN THE FUNCTION OF NATURAL-KILLER-CELLS [J].

ANDERSON, SK ;

GALLINGER, S ;

RODER, J ;

FREY, J ;

YOUNG, HA ;

ORTALDO, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :542-546

[2] Cyclophilins and their possible role in the stress response [J].

Andreeva, L ;

Heads, R ;

Green, CJ .

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 1999, 80 (06) :305-315

[3] Cyclophilin a peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export [J].

Ansari, H ;

Greco, G ;

Luban, J .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (20) :6993-7003

[4] Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase [J].

Arévalo-Rodríguez, M ;

Cardenas, ME ;

Wu, XY ;

Hanes, SD ;

Heitman, J .

EMBO JOURNAL, 2000, 19 (14) :3739-3749

[5] Prolyl isomerases in yeast [J].

Arevalo-Rodriguez, M ;

Wu, XY ;

Hanes, SD ;

Heitman, J .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 :2420-2446

[6] Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae [J].

Arévalo-Rodríguez, M ;

Heitman, J .

EUKARYOTIC CELL, 2005, 4 (01) :17-29

[7] Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J].

Baines, CP ;

Kaiser, RA ;

Purcell, NH ;

Blair, NS ;

Osinska, H ;

Hambleton, MA ;

Brunskill, EW ;

Sayen, MR ;

Gottlieb, RA ;

Dorn, GW ;

Robbins, J ;

Molkentin, JD .

NATURE, 2005, 434 (7033) :658-662

[8] Properties of the permeability transition pore in mitochondria devoid of cyclophilin D [J].

Basso, E ;

Fante, L ;

Fowlkes, J ;

Petronilli, V ;

Forte, MA ;

Bernardi, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :18558-18561

[9] Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A [J].

Bosco, DA ;

Eisenmesser, EZ ;

Pochapsky, S ;

Sundquist, WI ;

Kern, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5247-5252

[10] Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells [J].

Braaten, D ;

Luban, J .

EMBO JOURNAL, 2001, 20 (06) :1300-1309

← 1 2 3 4 5 6 7 8 →