Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

被引：43

作者：

Ito, C

Shen, H

Toyota, H

Kubota, Y

Sakurai, E

Watanabe, T

Sato, M

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Cellular Pharmacol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Psychiat, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 262卷 / 02期

关键词：

histamine; histamine N-methyltransferase; restraint stresses; Fischer rat brain; stress vulnerability;

D O I：

10.1016/S0304-3940(99)00052-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N-methyltransferase activities in the nucleus accumbens and striatum, The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum, These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 145

页数：3

共 23 条

[1] BLOCKADE OF MUSCARINIC, HISTAMINE-H1 AND HISTAMINE-H2 RECEPTORS BY ANTIDEPRESSANTS [J].