Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis

被引：98

作者：

Kojima, Ayuchi ^{[1
,2
]}

Nakano, Kazuhiko ^{[2
]}

Wada, Koichiro ^{[1
]}

Takahashi, Hirokazu ^{[3
]}

Katayama, Kazufumi ^{[1
,4
]}

Yoneda, Masato ^{[3
]}

Higurashi, Takuma ^{[3
]}

Nomura, Ryota ^{[2
]}

Hokamura, Kazuya ^{[5
]}

Muranaka, Yoshinori ^{[6
]}

Matsuhashi, Nobuyuki ^{[7
]}

Umemura, Kazuo ^{[5
]}

Kamisaki, Yoshinori ^{[1
]}

Nakajima, Atsushi ^{[3
]}

Ooshima, Takashi ^{[2
]}

机构：

[1] Osaka Univ, Dept Pharmacol, Grad Sch Dent, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Pediat Dent, Grad Sch Dent, Suita, Osaka 5650871, Japan

[3] Yokohama City Univ, Sch Med, Div Gastroenterol, Yokohama, Kanagawa 2360004, Japan

[4] Osaka Univ, Dept Biol Chem, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[5] Hamamatsu Univ Sch Med, Dept Pharmacol, Hamamatsu, Shizuoka 4313192, Japan

[6] Hamamatsu Univ Sch Med, Lab Ultrastruct Res, Hamamatsu, Shizuoka 4313192, Japan

[7] NTT E, Kanto Med Ctr, Dept Gastroenterol, Tokyo 1418625, Japan

来源：

SCIENTIFIC REPORTS | 2012年 / 2卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; PORPHYROMONAS-GINGIVALIS; PPAR-GAMMA; SEROTYPE; MECHANISMS; THERAPY;

D O I：

10.1038/srep00332

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans, caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-gamma in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans-mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.

引用

页数：11

共 28 条

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