Microbes inside-from diversity to function: the case of Akkermansia

被引:520
作者
Belzer, Clara [1 ]
de Vos, Willem M. [1 ,2 ,3 ]
机构
[1] Univ Wageningen & Res Ctr, Microbiol Lab, NL-6703 HB Wageningen, Netherlands
[2] Univ Helsinki, Dept Vet Biosci, Helsinki, Finland
[3] Univ Helsinki, Dept Bacteriol & Immunol, Helsinki, Finland
基金
欧洲研究理事会;
关键词
intestinal microbiota; functional metagenomics; anaerobic consortia; human microbe cross talk: Akkermansia muciniphila; HUMAN GUT MICROBIOTA; GASTROINTESTINAL-TRACT MICROBIOTA; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; IDENTICAL-TWINS; CROHNS-DISEASE; BACTERIA; MUCIN; MUCINIPHILA; MICE;
D O I
10.1038/ismej.2012.6
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
The human intestinal tract is colonized by a myriad of microbes that have developed intimate interactions with the host. In healthy individuals, this complex ecosystem remains stable and resilient to stressors. There is significant attention on the understanding of the composition and function of this intestinal microbiota in health and disease. Current developments in metaomics and systems biology approaches allow to probe the functional potential and activity of the intestinal microbiota. However, all these approaches inherently suffer from the fact that the information on macromolecules (DNA, RNA and protein) is collected at the ecosystem level. Similarly, all physiological and other information collected from isolated strains relates to pure cultures grown in vitro or in gnotobiotic systems. It is essential to integrate these two worlds of predominantly chemistry and biology by linking the molecules to the cells. Here, we will address the integration of omics- and culture-based approaches with the complexity of the human intestinal microbiota in mind and the mucus-degrading bacteria Akkermansia spp. as a paradigm. The ISME Journal (2012) 6, 1449-1458; doi: 10.1038/ismej.2012.6; published online 22 March 2012
引用
收藏
页码:1449 / 1458
页数:10
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