RadC, a misleading name?

被引:32
作者
Attaiech, Laetitia [1 ]
Granadel, Chantal [1 ]
Claverys, Jean-Pierre [1 ]
Martin, Bernard [1 ]
机构
[1] Univ Toulouse 3, CNRS, UMR 5100, Lab Microbiol & Genet Mol, F-31062 Toulouse 9, France
关键词
D O I
10.1128/JB.00425-08
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The pfam04002 annotation describes RadC as a bacterial DNA repair protein. Although the radC gene is expressed specifically during competence for genetic transformation in Streptococcus pneumoniae, we report that radC mutants exhibit normal uptake and processing of transforming DNA. They also display normal sensitivity to DNA-damaging agents, providing no support for the rad epithet.
引用
收藏
页码:5729 / 5732
页数:4
相关论文
共 23 条
[1]   Transformation of Streptococcus pneumoniae relies on DprA- and RecA-dependent protection of incoming DNA single strands [J].
Bergé, M ;
Mortier-Barrière, I ;
Martin, B ;
Claverys, JP .
MOLECULAR MICROBIOLOGY, 2003, 50 (02) :527-536
[2]   Uptake of transforming DNA in Gram-positive bacteria:: a view from Streptococcus pneumoniae [J].
Bergé, M ;
Moscoso, M ;
Prudhomme, M ;
Martin, B ;
Claverys, JP .
MOLECULAR MICROBIOLOGY, 2002, 45 (02) :411-421
[3]   Microarray analysis of the Bacillus subtilis K-state:: genome-wide expression changes dependent on ComK [J].
Berka, RM ;
Hahn, J ;
Albano, M ;
Draskovic, I ;
Persuh, M ;
Cui, XJ ;
Sloma, A ;
Widner, W ;
Dubnau, D .
MOLECULAR MICROBIOLOGY, 2002, 43 (05) :1331-1345
[4]  
CLAVERYS JP, 1986, MICROBIOL REV, V50, P133, DOI 10.1128/MMBR.50.2.133-165.1986
[5]   CHARACTERIZATION OF A NEW RADIATION-SENSITIVE MUTANT, ESCHERICHIA-COLI K-12 RADC102 [J].
FELZENSZWALB, I ;
SARGENTINI, NJ ;
SMITH, KC .
RADIATION RESEARCH, 1984, 97 (03) :615-625
[6]   Inhibition of competence development in Streptococcus pneumoniae by increased basal-level expression of the ComDE two-component regulatory system [J].
Guiral, S ;
Hénard, V ;
Granadel, C ;
Martin, B ;
Claverys, JP .
MICROBIOLOGY-SGM, 2006, 152 :323-331
[7]   Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach [J].
Hamoen, LW ;
Smits, WK ;
de Jong, A ;
Holsappel, S ;
Kuipers, OP .
NUCLEIC ACIDS RESEARCH, 2002, 30 (24) :5517-5528
[8]   AN UNMODIFIED HEPTADECAPEPTIDE PHEROMONE INDUCES COMPETENCE FOR GENETIC-TRANSFORMATION IN STREPTOCOCCUS-PNEUMONIAE [J].
HAVARSTEIN, LS ;
COOMARASWAMY, G ;
MORRISON, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11140-11144
[9]   SigM-Responsive genes of Bacillus subtilis and their promoters [J].
Jervis, Adrian J. ;
Thackray, Penny D. ;
Houston, Chris W. ;
Horsburgh, Malcolm J. ;
Moir, Anne .
JOURNAL OF BACTERIOLOGY, 2007, 189 (12) :4534-4538
[10]  
Katsiou E, 1999, MICROBIOL RES, V154, P233