B cells: No longer the nondominant arm of multiple sclerosis

被引：11

作者：

Klawiter, Eric C. ^{[1
]}

Cross, Anne H. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2007年 / 7卷 / 03期

关键词：

D O I：

10.1007/s11910-007-0035-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving. Recent discoveries include advances in lesion classification, identification of B cell clonal expansion in the central nervous system with evidence of antigen targeting, identification of chemokines in MS lesions, and expansion of information on the roles of autoantibodies and complement. Strong indications are accumulating that a greater degree of humoral dysfunction may lead to worsened long-term prognosis in MS. Effects of established MS treatments on B cells and their products have been further defined. Treatments that specifically target B cells are being implemented and hold promise.

引用

页码：231 / 238

页数：8

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