Does Helicobacter pylori infection play a role in lung cancer?

被引：35

作者：

Ece, F ^{[1
]}

Hatabay, NF ^{[1
]}

Erdal, N ^{[1
]}

Gedik, C ^{[1
]}

Guney, C ^{[1
]}

Aksoy, F ^{[1
]}

机构：

[1] SSK Sureyyapasa Chest Dis Hosp, Dept Pulm Oncol, Istanbul, Turkey

来源：

RESPIRATORY MEDICINE | 2005年 / 99卷 / 10期

关键词：

Helicobacter pylori; CagA; VacA; non-small cell lung cancer;

D O I：

10.1016/j.rmed.2005.02.038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Helicobacter pylori infection is a world-wide common disease and leads to many gastrointestinal and respiratory illnesses. It is suggested that one of these respiratory illnesses is lung cancer. Methods: Forty-three patients with non-small cell Lung cancer and 28 control subjects have been included to this study. H. pylori status of the patients and controls was determined by immunoblot for the detection of IgG (RIDA Blot Helicobacter). All subjects were examined to evaluate the presence of VacA and CagA gene. Results: Seropositivity of anti H. pylori IgG was significantly higher in cancer patients than in control groups, 40 (93%) and 12 (42%), respectively (P<0.01). Although both VacA and CagA seropositivity was high in lung cancer patients, only VacA positivity was statistically significant when compared with control subjects, 35 (81%) and 11 (42%), respectively (P<0.05). Conclusion: H. pylori infection may be associated with development of lung cancer. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1258 / 1262

页数：5

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