The odyssey of MeCP2 and parental imprinting

被引：30

作者：

LaSalle, Janine M.

机构：

[1] Medical Microbiology and Immunology, Davis, CA 95616, One Shields Avenue

来源：

EPIGENETICS | 2007年 / 2卷 / 01期

关键词：

parental imprinting; DNA methylation; neurodevelopment; methyl CpG binding protein; epigenetic;

D O I：

10.4161/epi.2.1.3697

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

DNA methylation in mammals has long been implicated in the epigenetic mechanism of parental imprinting, in which selective expression of one allele of specific genes is based on parental origin. Methyl CpG binding protein 2 (MeCP2) selectively binds to methylated DNA and mutations in the MECP2 cause the autism-spectrum neurodevelopmental disorder Rett syndrome. This review outlines the emerging story of how MeCP2 has been implicated in the regulation of specific imprinted genes and loci, including UBE3A and DLX5. The story of MeCP2 and parental imprinting has unfolded with some interesting but unexpected twists, revealing new insights on the function of MeCP2 in the process.

引用

收藏

页码：5 / 10

页数：6

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