Fibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection

被引：64

作者：

Steiling, H ^{[1
]}

Werner, S ^{[1
]}

机构：

[1] ETH, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2003年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.copbio.2003.08.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factors (FGFs) regulate early development and organogenesis. In particular, a subfamily of FGFs is essential for the formation and differentiation of epithelial tissues and organs. Recent studies revealed a crucial role for these FGFs in repair of the skin, intestine and liver. In addition, the cytoprotective potential of FGFs suggests their use for the protection of epithelial cells under conditions of stress in vivo. Indeed, the first successful clinical trials using FGFs for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage have been announced.

引用

页码：533 / 537

页数：5

共 49 条

[1]

Abraham J. A., 1996, MOL CELLULAR BIOL WO, P195

[2]

Alzheimer C, 2002, ADV EXP MED BIOL, V513, P335

[3] Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development [J].

Arman, E ;

Haffner-Krausz, R ;

Chen, Y ;

Heath, JK ;

Lonai, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :5082-5087

[4] THE FGF FAMILY OF GROWTH-FACTORS AND ONCOGENES [J].

BASILICO, C ;

MOSCATELLI, D .

ADVANCES IN CANCER RESEARCH, 1992, 59 :115-165

[5] Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression [J].

Beer, HD ;

Florence, C ;

Dammeier, J ;

McGuire, L ;

Werner, S ;

Duan, DR .

ONCOGENE, 1997, 15 (18) :2211-2218

[6] Fibroblast growth factor 22 and its potential role during skin development and repair [J].

Beyer, TA ;

Werner, S ;

Dickson, C ;

Grose, R .

EXPERIMENTAL CELL RESEARCH, 2003, 287 (02) :228-236

[7] MODULATION OF EPITHELIAL-CELL GROWTH BY INTRAEPITHELIAL GAMMA-DELTA T-CELLS [J].

BOISMENU, R ;

HAVRAN, WL .

SCIENCE, 1994, 266 (5188) :1253-1255

[8]

Brauchle M, 1996, AM J PATHOL, V149, P521

[9] Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound [J].

Braun, S ;

Hanselmann, C ;

Gassmann, MG ;

Keller, UAD ;

Born-Berclaz, C ;

Chan, KM ;

Kan, YW ;

Werner, S .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (15) :5492-5505

[10] Protection of the intestinal mucosa by intraepithelial γδ T cells [J].

Chen, YP ;

Chou, K ;

Fuchs, E ;

Havran, WL ;

Boismenu, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14338-14343

← 1 2 3 4 5 →