Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum

被引：833

作者：

Alkilani, Ahlam Zaid ^{[1
,2
]}

McCrudden, Maeliosa T. C. ^{[1
]}

Donnelly, Ryan F. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland

[2] Zarqa Univ, Fac Pharm, Zarqa 132222, Jordan

来源：

PHARMACEUTICS | 2015年 / 7卷 / 04期

关键词：

transdermal; drug delivery; velocity based device; ultrasound; thermal ablation; mechanical and electrical approaches; microneedle; FORMING MICRONEEDLE ARRAYS; EXCISED HUMAN-SKIN; IONTOPHORETIC DELIVERY; IN-VITRO; DISSOLVING MICRONEEDLES; FABRICATION PROCESS; HYALURONIC-ACID; AMINO-ACIDS; TECHNOLOGIES; ELECTROPORATION;

D O I：

10.3390/pharmaceutics7040438

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.

引用

页码：438 / 470

页数：33

共 155 条

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