Novel inhaled combined antibiotic formulations in the treatment of Pseudomonas aeruginosa airways infections in cystic fibrosis

被引：23

作者：

Antoniu, Sabina ^{[1
]}

机构：

[1] Univ Med & Pharm, Dept Interdisciplinary Palliat Care Nursing, Iasi 700115, Romania

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2015年 / 13卷 / 07期

关键词：

cystic fibrosis; fosfomycin; tobramycin; inhaled antibiotics; Pseudomonas aeruginosa; TOBRAMYCIN INHALATION POWDER; CLARITHROMYCIN THERAPY; ALVEOLAR MACROPHAGES; EFFICIENT DELIVERY; DRY POWDER; FOSFOMYCIN; AMIKACIN; COMBINATION; MACROLIDE; EFFICACY;

D O I：

10.1586/14787210.2015.1041925

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

In cystic fibrosis, chronic airways infection caused by Pseudomonas aeruginosa can be treated with inhaled antibiotics such as inhaled tobramycin, aztreonam or colistin. However, biofilm formation induced by this bacterium can reduce the effectiveness of such therapies and can contribute to antibiotic resistance. Inhaled antibiotic combination might represent an optimal antibiofilm strategy in this setting. This review discusses the rationale for combining the antibiotics as well as some emerging or existing combinations. Most of the combinations except for fosfomycin/tobramycin are at an early stage of development. The latter combination was found to be effective in Phase II clinical studies and is planned to be tested in Phase III trials. The clinical data on long-term efficacy are currently missing, but the existing evidence as well as the unmet therapeutic need can prompt the further evaluation of such compounds.

引用

页码：897 / 905

页数：9

共 59 条

[1]

Efficacy and Safety of Liposomal Clarithromycin and Its Effect on Pseudomonas aeruginosa Virulence Factors [J].

Alhajlan, Mai ;

Alhariri, Moayad ;

Omri, Abdelwahab .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (06) :2694-2704

[2]

Eradication of Pseudomonas aeruginosa biofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination [J].

Anderson, Gregory G. ;

Kenney, Thomas F. ;

MacLeod, David L. ;

Henig, Noreen R. ;

O'Toole, George A. .

PATHOGENS AND DISEASE, 2013, 67 (01) :39-45

[3]

[Anonymous], 2014, 2014 IEEE 8th Int. Conf. on Application of Information and Communication Technologies (AICT), DOI DOI 10.1109/ICAICT.2014.7036000

[4]

NOVEL AMIKACIN INHALED FORMULATION FOR THE TREATMENT OF LOWER RESPIRATORY TRACT INFECTIONS [J].

Antoniu, S. ;

Azoicai, D. .

DRUGS OF TODAY, 2013, 49 (11) :683-692

[5]

Inhaled colistin for lower respiratory tract infections [J].

Antoniu, Sabina Antonela ;

Cojocaru, Ileana .

EXPERT OPINION ON DRUG DELIVERY, 2012, 9 (03) :333-342

[6]

Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis [J].

Barker, AF ;

Couch, L ;

Fiel, SB ;

Gotfried, MH ;

Ilowite, J ;

Meyer, KC ;

O'Donnell, A ;

Sahn, SA ;

Smith, LJ ;

Stewart, JO ;

Abuan, T ;

Tully, H ;

Van Dalfsen, J ;

Wells, CD ;

Quan, J .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (02) :481-485

[7]

Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection [J].

Clancy, J. P. ;

Dupont, L. ;

Konstan, M. W. ;

Billings, J. ;

Fustik, S. ;

Goss, C. H. ;

Lymp, J. ;

Minic, P. ;

Quittner, A. L. ;

Rubenstein, R. C. ;

Young, K. R. ;

Saiman, L. ;

Burns, J. L. ;

Govan, J. R. W. ;

Ramsey, B. ;

Gupta, R. .

THORAX, 2013, 68 (09) :818-825

[8]

Tobramycin Nebulizer Solution in Severe COPD Patients Colonized with Pseudomonas Aeruginosa: Effects on Bronchial Inflammation [J].

Dal Negro, Roberto ;

Micheletto, Claudio ;

Tognella, Silvia ;

Visconti, Marilia ;

Turati, Claudio .

ADVANCES IN THERAPY, 2008, 25 (10) :1019-1030

[9]

Dhand R, 2007, RESP CARE, V52, P866

[10]

DUPONT L, 2010, AM J RESP CRIT CARE, V181, pA1836

← 1 2 3 4 5 6 →