Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod

被引：223

作者：

Wagner, TL ^{[1
]}

Ahonen, CL ^{[1
]}

Couture, AM ^{[1
]}

Gibson, SJ ^{[1
]}

Miller, RL ^{[1
]}

Smith, RM ^{[1
]}

Reiter, MJ ^{[1
]}

Vasilakos, JP ^{[1
]}

Tomai, MA ^{[1
]}

机构：

[1] 3M Pharmaceut, Dept Pharmacol, St Paul, MN 55144 USA

来源：

CELLULAR IMMUNOLOGY | 1999年 / 191卷 / 01期

关键词：

D O I：

10.1006/cimm.1998.1406

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cytokines produced by antigen-presenting cells are known to affect the development and cytokine profile of T cells. The immune response modifiers imiquimod and R-848 were previously shown to stimulate human and mouse cultures to secrete interferon-alpha. Results from the present study demonstrate that R-848 and imiquimod are capable of inducing interleukin-la and interferon-gamma in mouse and human cell cultures. Both CD4(+) and CD8(+) T lymphocytes were responsible for producing IFN-gamma following stimulation with R-848. Macrophages were required for induction of interferon-gamma by R-848 and the cytokines IFN-alpha and IL-12 mediated this response. R-848 and imiquimod were also found to inhibit IL-4 and IL-5 production in mouse and human culture systems. The inhibition of IL-5 in response to R-848 is seen in cultures containing CD4(+) lymphocytes and macrophages and is mediated in part by IFN-alpha. These data suggest that imiquimod and R-848 may have clinical utility in diseases where cell-mediated immune responses are important and in diseases associated with overexpression of IL-4 or IL-5 such as atopic disease. (C) 1999 Academic Press.

引用

页码：10 / 19

页数：10

共 36 条

[1] EFFECT OF IMIQUIMOD AS AN ADJUVANT FOR IMMUNOTHERAPY OF GENITAL HSV IN GUINEA-PIGS [J].