Divergence and Convergence in Enzyme Evolution: Parallel Evolution of Paraoxonases from Quorum-quenching Lactonases

被引：95

作者：

Elias, Mikael ^{[1
]}

Tawfik, Dan S. ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 01期

基金：

以色列科学基金会;

关键词：

ARCHAEON SULFOLOBUS-SOLFATARICUS; UNIVERSAL COMMON ANCESTOR; AMIDOHYDROLASE SUPERFAMILY; DIRECTED EVOLUTION; BACILLUS-THURINGIENSIS; DEINOCOCCUS-RADIODURANS; 3-DIMENSIONAL STRUCTURE; CATALYTIC DIVERSITY; ENOLASE SUPERFAMILY; PHOSPHOTRIESTERASE;

D O I：

10.1074/jbc.R111.257329

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We discuss the basic features of divergent versus convergent evolution and of the common scenario of parallel evolution. The example of quorum-quenching lactonases is subsequently described. Three different quorum-quenching lactonase families are known, and they belong to three different superfamilies. Their key active-site architectures have converged and are strikingly similar. Curiously, a promiscuous organophosphate hydrolase activity is observed in all three families. We describe the structural and mechanistic features that underline this converged promiscuity and how this promiscuity drove the parallel divergence of organophosphate hydrolases within these lactonase families by either natural or laboratory evolution.

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页码：11 / 20

页数：10

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