If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung

被引：44

作者：

Downey, Paul ^{[1
]}

Cummins, Robert ^{[2
]}

Moran, Margaret ^{[1
]}

Gulmann, Christian ^{[1
]}

机构：

[1] Beaumont Hosp, Dept Pathol, Dublin 9, Ireland

[2] Royal Coll Surgeons Ireland, Dept Pathol, Dublin 2, Ireland

来源：

APMIS | 2008年 / 116卷 / 06期

关键词：

lung cancer; CK5/6; TTF-1; squamous cell carcinoma; adenocarcinoma;

D O I：

10.1111/j.1600-0463.2008.00932.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Novel targeted treatment of non-small cell lung cancer (NSCLC) requires accurate classification of NSCLC as squamous cell carcinoma (SCC) and adenocarcinoma (AC). This study details the CK5/6 and TTF-1 immunoprofile of surgical resections of 45 NSCLCs (24 ACs and 21 SCCs) in tissue microarrays. All SCCs were CK5/6 positive, TTF-1 negative. 20 of 24 adenocarcinomas had the reverse pattern. In conclusion, all SCCs in this study were CK5/6 positive and TTF-1 negative, and therefore tumours that do not display this phenotype are unlikely to be SCCs. CK5/6 and TTF-1 is therefore a practical panel for the distinction between pulmonary SCC from AC in routine histopathology practice.

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收藏

页码：526 / 529

页数：4

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