Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat

被引：87

作者：

Escudero, Elizabeth ^{[1
,2
]}

Toldra, Fidel ^{[2
]}

Angel Sentandreu, Miguel ^{[2
]}

Nishimura, Hitoshi ^{[1
]}

Arihara, Keizo ^{[1
]}

机构：

[1] Kitasato Univ, Sch Vet Med, Fac Anim Sci, Towada, Aomori 0348628, Japan

[2] CSIC, Inst Agroquim & Tecnol Alimentos, Valencia 46980, Spain

来源：

MEAT SCIENCE | 2012年 / 91卷 / 03期

基金：

日本学术振兴会;

关键词：

Antihypertensive activity; Peptide; Pork meat; Angiotensin I-converting enzyme; Spontaneously hypertensive rat; SPONTANEOUSLY HYPERTENSIVE-RATS;

D O I：

10.1016/j.meatsci.2012.02.007

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

This study investigated the in vivo antihypertensive activity of three novel peptides identified in the in vitro digest of pork meat. These peptides were RPR, KAPVA and PTPVP and all of them showed significant antihypertensive activity after oral administration to spontaneously hypertensive rats. RPR being the peptide with the greatest in vivo activity. To our knowledge, this is the first report showing the in vivo antihypertensive action of the three peptides from nebulin (RPR) and titin (KAPVA and PTPVP), thus confirming their reported in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. These findings suggest that pork meat could constitute a source of bioactive constituents that could be utilized in functional foods or nutraceuticals. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：382 / 384

页数：3

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