Two circadian oscillatory mechanisms in the mammalian retina

被引：41

作者：

Sakamoto, K

Oishi, K

Shiraishi, M

Hamano, S

Otsuka, H

Miyake, Y

Ishida, N

机构：

[1] MITI, Agcy Ind Sci & Technol, Natl Inst Biosci & Human Technol, Ishida Grp Clock Gene, Tsukuba, Ibaraki 3058566, Japan

[2] Nihon Univ, Sch Med, Dept Obstet & Gynecol, Itabashi Ku, Tokyo 1730032, Japan

[3] Japan Sci & Technol Corp, Tokyo, Japan

[4] Tokyo Inst Technol, Dept Biomol Engn, Yokohama, Kanagawa 2268501, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 18期

关键词：

circadian rhythms; mammals; Period; retina; serotonin N-acetyltransferase;

D O I：

10.1097/00001756-200012180-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the mechanism that controls circadian rhythms in the mammalian retina, we examined the mRNA expression rhythms of serotonin N-acetyltransferase (NAT), the mammalian clock gene rPer2 and a clock-controlled gene Dbp in the retina of rats with lesions of the suprachiasmatic nucleus (SCN), the master clock in mammals. Northern blot analyses showed that retinal NAT mRNA still exhibited the circadian in the SCN-lesioned rats, whereas the lesion abolished the rhythms of rPer2 and Dbp mRNAs. These findings suggest that the mammalian retina has two circadian oscillatory mechanisms: one can generate rhythmicity independent of the SCN and the other requires the SCN to maintain circadian oscillation. NeuroReport 11:3995-3997 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3995 / 3997

页数：3

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