Sequence analysis of the MHC class I region reveals the basis of the genomic matching technique

被引:15
作者
Gaudieri, S [1 ]
Longman-Jacobsen, N [1 ]
Tay, GK [1 ]
Dawkins, RL [1 ]
机构
[1] Univ Western Australia, Ctr Mol Immunol & Instrumentat, Canning Vale, WA 6155, Australia
基金
英国医学研究理事会;
关键词
bone marrow transplantation; genomic matching technique; MHC; segmental duplication; PERB11;
D O I
10.1016/S0198-8859(01)00210-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The genomic matching technique (GMT) improves survival following bone marrow transplantation (BMT) between unrelated donor and recipient pairs correlating with a decrease in incidence and severity of graft-versus-host disease (GVHD). The principles of this technique are based on the duplication and polymorphic characteristics of the major histocompatibility complex ((MHC). Specifically, the beta block GMT matches for a 300 kb region that contains the human leukocyte antigen (HLA-B and -C) genes as well as other non-HLA genes such as the natural killer cell receptor ligand PERB11 (MIC). The block contains two large segmental duplications. One results in two PERB11 genes(11.1 and 11.2), the other in two class I genes (HLA-B and -C). With the complete sequencing of the class I region of the MHC in different haplotypes, me can now show that tl-ie beta block GMT profiles reflect amplification of the duplicated PERB11 segments and not the duplicated segments containing HLA-B and -C, and yet provide a signature that characterizes the entire block rather than individual loci, Human Immunology 62, 279-285 (2001). (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.
引用
收藏
页码:279 / 285
页数:7
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