Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

被引：324

作者：

Manganas, Louis N.

Zhang, Xueying

Li, Yao

Hazel, Raphael D.

Smith, S. David

Wagshul, Mark E.

Henn, Fritz

Benveniste, Helene

Djuric, Petar M.

Enikolopov, Grigori ^{[1
]}

Maletic-Savatic, Mirjana

机构：

[1] SUNY Stony Brook, Stony Brook, NY 11794 USA

[2] Brookhaven Natl Lab, Upton, NY 11719 USA

[3] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

SCIENCE | 2007年 / 318卷 / 5852期

关键词：

D O I：

10.1126/science.1147851

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

引用

收藏

页码：980 / 985

页数：6

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