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Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion

被引：16
作者：
Okazuka, Kiyoshi
Masuko, Masayoshi
Seki, Yoshinobu
Hama, Hitomi
Honma, Noriyuki
Furukawa, Tatsuo
Toba, Ken
Kishi, Kenji
Aizawa, Yoshifusa
机构：
[1] Niigata Univ, Med & Dent Hosp, Div Hematol, Niigata 9518520, Japan
[2] Shibata Prefectural Hosp, Div Internal Med, Niigata, Japan
[3] Niigata Univ, Med & Dent Hosp, Div Bone Marrow Transplantat, Niigata, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 03期
关键词：
acute promyelocytic leukemia; nucleophosmin-retinoic acid receptor fusion; chronic renal failure;
D O I：
10.1007/BF03006928
中图分类号：
R5 [内科学];
学科分类号：
1002 [临床医学]; 100201 [内科学];
摘要：
Acute promyelocytic leukemia (APL) is characterized by a reciprocal chromosomal translocation involving the gene for retinoic acid receptor alpha (RAR). Most APL patients have a t(15;17) translocation that generates the PML-RAR fusion gene, and such patients respond well to treatment with all-trans retinoic acid (ATRA). Some APL cases also involve rearrangements that fuse RAR to partner genes other than PML, including nucleophosmin (NPM), promyelocytic leukemia zinc finger (PLZF), nuclear mitotic apparatus (NUMA), and Stat5b, but the clinical characteristics of APL without PML-RAR have not been fully clarified. We describe a 64-year-old man with NPM-RAR-positive APL who was receiving hemodialysis therapy for chronic uremia. Complete remission was achieved with ATRA monotherapy and was maintained for 18 months with consolidation chemotherapy. These findings suggest that ATRA can be used to treat APL patients with NPM/RAR as well as APL with PML/RAR.
引用
收藏
页码：246 / 249
页数：4
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