Molecular Imaging in Radiotherapy Planning for Head and Neck Tumors

被引：22

作者：

Gregoire, Vincent ^{[1
]}

Chiti, Arturo ^{[2
]}

机构：

[1] Catholic Univ Louvain, St Luc Univ Hosp, Dept Radiat Oncol, Ctr Mol Imaging & Expt Radiotherapy IMRE, B-1200 Brussels, Belgium

[2] Ist Clin Humanitas, Dept Nucl Med, Rozzano Milan, Italy

来源：

JOURNAL OF NUCLEAR MEDICINE | 2011年 / 52卷 / 03期

关键词：

PET; FDG; radiotherapy; target volume delineation; dose painting; SQUAMOUS-CELL CARCINOMA; POSITRON-EMISSION-TOMOGRAPHY; DOSE DISTRIBUTION; FDG-PET; CANCER; DELINEATION; CT; VALIDATION; MANAGEMENT; IMPACT;

D O I：

10.2967/jnumed.110.075689

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Molecular imaging uses noninvasive techniques to visualize various biologic pathways and physiologic characteristics of tumors and normal tissues. In relation to radiation therapy, PET with the tracer F-18-FDG offers a unique opportunity to refine the target volume delineation in patients with squamous cell carcinoma of the head and neck, in turn affecting dose distribution and, it is hoped, patient outcome. Even more so, in the framework of adaptive treatment and theragnostics, whereby dose distribution is adapted in space and time over the typical course of radiotherapy, molecular imaging with PET offers an elegant research avenue to further improve the therapeutic ratio. Such implementation could be of particular interest with tracers other than F-18-FDG, such as tracers of hypoxia and proliferation.

引用

页码：331 / 334

页数：4

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