Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome

被引：132

作者：

van Balkom, BWM

van Gestel, RA

Brouwers, JFHM

Krijgsveld, J

Tielens, AGM

Heck, AJR

van Hellemond, JJ

机构：

[1] Univ Utrecht, Dept Biomol Mass Spectrometry, Bijvoet Ctr Biomol Res, NL-3584 CA Utrecht, Netherlands

[2] Univ Utrecht, Inst Pharmaceut Sci, NL-3584 CA Utrecht, Netherlands

[3] GSAH, IVW, Vet Res Inst, NL-3508 TD Utrecht, Netherlands

[4] Univ Utrecht, Dept Biochem & Cell Biol, Fac Med Vet, NL-3508 TD Utrecht, Netherlands

[5] Univ Utrecht, Inst Biomembranes, NL-3508 TD Utrecht, Netherlands

来源：

JOURNAL OF PROTEOME RESEARCH | 2005年 / 4卷 / 03期

关键词：

immune evasion; host-parasite interaction; schistosomiasis;

D O I：

10.1021/pr050036w

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival.

引用

收藏

页码：958 / 966

页数：9

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