Enantioselective synthesis of (+)-goniodiol and of its naturally occurring acetylated analogs

被引：33

作者：

Surivet, JP ^{[1
]}

Gore, J ^{[1
]}

Vatele, JM ^{[1
]}

机构：

[1] UNIV LYON 1,CPE LYON,CNRS,LAB CHIM ORGAN 1,F-69622 VILLEURBANNE,FRANCE

来源：

TETRAHEDRON | 1996年 / 52卷 / 47期

关键词：

D O I：

10.1016/0040-4020(96)00918-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route to enantioenriched (+)-goniodiol and its natural acetylated derivatives, potent cytotoxic compounds, is described. The main features of this synthesis are transfer of the asymmetric information of the scalemic allenic alcohol 5 to the alpha- and beta- carbons through highly diastereoselective reactions and introduction of the alpha,beta-unsaturated lactone moiety by the Ghosez' methodology. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：14877 / 14890

页数：14

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