Capsaicin-Coated Silver Nanoparticles Inhibit Amyloid Fibril Formation of Serum Albumin

被引：47

作者：

Anand, Bibin G. ^{[1
]}

Dubey, Kriti ^{[1
]}

Shekhawat, Dolat Singh ^{[1
]}

Kar, Karunakar ^{[1
]}

机构：

[1] Indian Inst Technol Jodhpur, Dept Biol, Ctr Biol Inspired Syst Sci, Old Residency Rd, Jodhpur 342011, Rajasthan, India

来源：

BIOCHEMISTRY | 2016年 / 55卷 / 24期

关键词：

PROTEIN AGGREGATION; GOLD NANOPARTICLES; GLOBULAR-PROTEINS; AMINO-ACIDS; BINDING; STABILITY; MECHANISM; PEPTIDES; DISEASE; SENSORS;

D O I：

10.1021/acs.biochem.6b00418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We have synthesized capsaicin-coated silver nanoparticles (AgNPs(Cap)) and have tested their anti-amyloid activity, considering serum albumin (BSA) as a model protein. We found that amyloid formation of BSA was strongly suppressed in the presence of AgNPs(Cap). However, isolated capsaicin and uncapped control nano particles did not show such an inhibition effect. Bioinforrnatics analysis reveals CH-pi and H-bonding interactions between capsaicin and BSA in the formation of the protein ligand complex. These results suggest the significance of surface functionalization of nanoparticles with capsaicin, which probably allows capsaicin to effectively interact with the key residues of the amyloidogenic core of BSA.

引用

收藏

页码：3345 / 3348

页数：4

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