Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

被引：259

作者：

Jiang, YW

Veschambre, P

Erdjument-Bromage, H

Tempst, P

Conaway, JW

Conaway, RC

Kornberg, RD

机构：

[1] Oklahoma Med Res Fdn, Howard Hughes Med Inst, Oklahoma City, OK 73104 USA

[2] Oklahoma Med Res Fdn, Program Mol & Cell Biol, Oklahoma City, OK 73104 USA

[3] Stanford Univ, Med Ctr, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA

[4] Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10021 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 15期

关键词：

MED genes; SRB genes; Ring-3; C-terminal domain; TFIIH kinase;

D O I：

10.1073/pnas.95.15.8538

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A multiprotein complex isolated from murine cells is identified as a counterpart of the yeast Mediator of transcriptional regulation on the basis of the following: homologs of two subunits of yeast Mediator, Srb7 and Med7, copurify with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator subunits Rgr1 and Med6; as with yeast Mediator, the mouse complex binds to the RNA polymerase II C-terminal domain (CTD) and stimulates phosphorylation of the CTD by TFIIH. Peptide sequencing also identifies a component of mouse Mediator as a relative of Ring-3 protein, a mitogen-activated nuclear protein kinase, raising the possibility of Mediator as an end point of signal transduction pathways.

引用

页码：8538 / 8543

页数：6

共 38 条

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