synthesis;
5-trifluoromethyluracil;
NMR spectroscopy;
mass spectrometry;
D O I:
10.1016/0022-1139(95)03386-6
中图分类号:
O61 [无机化学];
学科分类号:
070301 ;
081704 ;
摘要:
5-Trifluoromethyluracil, an important intermediate for the preparation of the antiviral trifluridine, is obtained by chlorinating thymine to give the new 2,4-dichloro-5-trichloromethylpyrimidine. Reacting the latter with hydrogen fluoride yields the new 2,4-difluoro-5-trifluoromethylpyrimidine, and hydrolysis with water gives 5-trifluoromethyluracil in high purity and good yield.