A new synthesis of 5-trifluoromethyluracil

被引:22
作者
Andres, P
Marhold, A
机构
[1] Central Research Department, Bayer AG
关键词
synthesis; 5-trifluoromethyluracil; NMR spectroscopy; mass spectrometry;
D O I
10.1016/0022-1139(95)03386-6
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
5-Trifluoromethyluracil, an important intermediate for the preparation of the antiviral trifluridine, is obtained by chlorinating thymine to give the new 2,4-dichloro-5-trichloromethylpyrimidine. Reacting the latter with hydrogen fluoride yields the new 2,4-difluoro-5-trifluoromethylpyrimidine, and hydrolysis with water gives 5-trifluoromethyluracil in high purity and good yield.
引用
收藏
页码:93 / 95
页数:3
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