Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy

被引:136
作者
Gaffney, DK
Holden, J
Davis, M
Zempolich, K
Murphy, KJ
Dodson, M
机构
[1] Univ Utah, Dept Radiat Oncol, Salt Lake City, UT 84132 USA
[2] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA
[3] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT 84132 USA
[4] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84132 USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2001年 / 49卷 / 05期
关键词
COX-2; cervix cancer; radiation therapy; survival;
D O I
10.1016/S0360-3016(00)01583-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The purpose of this study,vas to examine the relationship between overall survival and prognostic factors in carcinoma of the cervix treated with radiation therapy. A clinicopathologic study was performed on 24 patients. Methods and Materials: Formalin-fixed, paraffin-embedded tumor biopsies were stained for Cyclooxygenase-2 (COX-2), Topoisomerase I, Topoisomerase II, and p53. Clinical factors such as stage, grade, tumor size, pre- and post-treatment hemoglobin level, and radiotherapy dose were also evaluated. Results: Median follow-up was 75 months for living patients. The only immunohistochemical or clinical factor that was associated with improved survival was decreased COX-2 distribution staining. High COX-2 distribution staining was associated,vith decreased overall survival (p = 0.021) and decreased disease-free survival (p = 0.015) by log-rank comparison of Kapian-Meier survival curves. The 5-year overall survival rates for tumors with low vs. high COX-2 distribution values were 75% and 35%, respectively. COX-2 staining intensity was found to correlate positively with tumor size (p = 0.022). Conclusion: These findings indicate that increased expression of COX-2 portends a diminished survival in patients with invasive carcinoma of the cervix treated with radiotherapy. Because COX-2 is an early-response gene involved in angiogenesis and inducible by different stimuli, these data may indicate opportunity to intervene with specific inhibitors of COX-2 in carcinoma of the cervix, (C) 2001 Elsevier Science.
引用
收藏
页码:1213 / 1217
页数:5
相关论文
共 15 条
  • [1] DeVita VT., 1997, CANC PRINCIPLES PRAC, V5th
  • [2] Elder DJE, 1997, CLIN CANCER RES, V3, P1679
  • [3] Gorski DH, 1999, CANCER RES, V59, P3374
  • [4] Kishi K, 2000, CANCER RES, V60, P1326
  • [5] Pathobiologic characteristics of hereditary breast cancer
    Lynch, BJ
    Holden, JA
    Buys, SS
    Neuhausen, SL
    Gaffney, DK
    [J]. HUMAN PATHOLOGY, 1998, 29 (10) : 1140 - 1144
  • [6] Lyng H, 2000, CLIN CANCER RES, V6, P1104
  • [7] Masferrer JL, 2000, CANCER RES, V60, P1306
  • [8] Enhancement of tumor response to γ-radiation by an inhibitor of cyclooxygenase-2 enzyme
    Milas, L
    Kishi, K
    Hunter, N
    Mason, K
    Masferrer, JL
    Tofilon, PJ
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (17) : 1501 - 1504
  • [9] Oka K, 2000, CANCER, V88, P2766, DOI 10.1002/1097-0142(20000615)88:12<2766::AID-CNCR15>3.0.CO
  • [10] 2-G