CRISPR - a widespread system that provides acquired resistance against phages in bacteria and archaea

被引：651

作者：

Sorek, Rotem ^{[1
]}

Kunin, Victor ^{[1
]}

Hugenholtz, Philip ^{[1
]}

机构：

[1] Joint Genome Inst, Walnut Creek, CA 94598 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 03期

关键词：

D O I：

10.1038/nrmicro1793

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Arrays of clustered, regularly interspaced short palindromic repeats (CRISPRs) are widespread in the genomes of many bacteria and almost all archaea. These arrays are composed of direct repeats that are separated by similarly sized non- repetitive spacers. CRISPR arrays, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism. This Progress discusses the structure and function of this newly recognized antiviral mechanism.

引用

页码：181 / 186

页数：6

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