Enantioselective approach to polyhydroxylated compounds using chiral sulfoxides:: Synthesis of enantiomerically pure myo-inositol and pyrrolidine derivatives

被引：45

作者：

Colobert, F

Tito, A

Khiar, N

Denni, D

Medina, MA

Martin-Lomas, M

Ruano, JLG

Solladié, G

机构：

[1] Univ Strasbourg 1, Ecole Europeenne Chim Polymeres & Mat, Lab Stereochim, Associe CNRS, F-67008 Strasbourg, France

[2] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

[3] CSIC, Inst Invest Quim, Seville 41092, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 24期

关键词：

D O I：

10.1021/jo9811569

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short enantioselective synthesis of the biologically important myo-inositol derivative I and the pyrrolidine derivative II is described. The molecule 3, a diketo disulfoxide readily made from tartaric acid, is the key intermediate. The sulfinyl group controlled completely the very high stereoselection observed.

引用

页码：8918 / 8921

页数：4

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