Prostaglandins and the myometrium and cervix

被引：79

作者：

Hertelendy, F ^{[1
]}

Zakár, T

机构：

[1] St Louis Univ, Sch Med, St Marys Hlth Ctr, Dept Obstet Gynecol & Womens Hlth, St Louis, MO 63117 USA

[2] Univ Newcastle, Mothers & Babies Res Ctr, Newcastle, NSW 2308, Australia

[3] Univ Newcastle, Dept Obstet & Gynecol, Newcastle, NSW 2308, Australia

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2004年 / 70卷 / 02期

关键词：

parturition; myometrium; prostaglandins; cervix; preterm labor; progesterone;

D O I：

10.1016/j.plefa.2003.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandins have long been thought to play important roles in the mechanism of parturition. Here we review the involvement of prostaglandins in myometrial and cervical functions with emphasis on human labor and birth. In addition, the cellular sources of prostaglandins as well as their interactions with various other endocrine, pracrine and physical factors, such as oxytocin, corticotropin releasing hormone, nitric oxide, platelet activating factor, cytokines, endothelin and stretch are also addressed together with their potential role in the molecular reorganization of cervical structure associated with labor and delivery. Finally, the premier role of progesterone in pregnancy maintenance and parturition is juxtaposed with the proposed "fine-tuning", modulatory role of prostaglandins and the above listed factors in the regulation of parturition. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：207 / 222

页数：16

共 169 条

[1]

ABRAMSON SB, 1991, J IMMUNOL, V147, P231

[2] Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells [J].