Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

被引：48

作者：

Lin, Yung-Kai ^{[2
]}

Chen, Ko-Hua ^{[3
]}

Ou, Keng-Liang ^{[1
]}

Liu, Min ^{[4
]}

机构：

[1] Taipei Med Univ, Grad Inst Biomed Mat & Engn, Res Ctr Biomed Implants & Microsurg Devices, Res Ctr Biomed Devices, Taipei 110, Taiwan

[2] Chinese Culture Univ, Dept Anim Sci, Taipei 11114, Taiwan

[3] Taipei Vet Gen Hosp, Dept Ophthalmol, Taipei 11217, Taiwan

[4] Chinese Culture Univ, Dept Life Sci, Taipei 11114, Taiwan

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2011年 / 26卷 / 05期

关键词：

bacterial cellulose; hydrogel; extracellular matrix; growth factor; wound healing; biodegradability; biocompatibility; MICROBIAL CELLULOSE; COLLAGEN; HYALURONAN; PRODUCTS; INJURY;

D O I：

10.1177/0883911511415390

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.

引用

页码：508 / 518

页数：11

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