The role of essential fatty acids in chronic fatigue syndrome - A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA

被引:56
作者
Warren, G
McKendrick, M
Peet, M
机构
[1] Univ Sheffield, Sect Psychiat, No Gen Hosp, Sheffield S5 7AU, S Yorkshire, England
[2] Cent Sheffield Univ Hosp NHS Trust, Dept Infect Dis & Med, Sheffield, S Yorkshire, England
来源
ACTA NEUROLOGICA SCANDINAVICA | 1999年 / 99卷 / 02期
关键词
chronic fatigue syndrome; essential fatty acids; treatment; aetiology;
D O I
10.1111/j.1600-0404.1999.tb00667.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective - To replicate the treatment study by Behan et al. (1990) using current research criteria for Chronic Fatigue Syndrome (CFS). Method - Fifty patients who fulfilled the Oxford Criteria for CFS were randomly allocated to treatment with either Efamol Marine or placebo for 3 months. They were seen monthly and completed a physical symptoms checklist and the Beck Inventory for Depression and reported if they were the same, better or worse at the end of the study. Results - Symptoms generally improved with time but. not significantly and there were no significant differences between the treatment and placebo groups. Pretreatment red-cell membrane (RBC) lipids of patients compared with age- and sex-matched normal controls showed no significant differences. Discussion - The results of this study contrast sharply with the previous study where 85% of patients had a clinically significant improvement of symptoms with Efamol Marine over a 3-month treatment period.
引用
收藏
页码:112 / 116
页数:5
相关论文
共 11 条
[1]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[2]   EFFECT OF HIGH-DOSES OF ESSENTIAL FATTY-ACIDS ON THE POSTVIRAL FATIGUE SYNDROME [J].
BEHAN, PO ;
BEHAN, WMH ;
HORROBIN, D .
ACTA NEUROLOGICA SCANDINAVICA, 1990, 82 (03) :209-216
[3]  
BEHAN PO, 1990, OMEGA, V6
[4]   POSTVIRAL FATIGUE SYNDROME - TIME FOR A NEW APPROACH [J].
DAVID, AS ;
WESSELY, S ;
PELOSI, AJ .
BRITISH MEDICAL JOURNAL, 1988, 296 (6623) :696-698
[5]   CHRONIC FATIGUE SYNDROME - A WORKING CASE DEFINITION [J].
HOLMES, GP ;
KAPLAN, JE ;
GANTZ, NM ;
KOMAROFF, AL ;
SCHONBERGER, LB ;
STRAUS, SE ;
JONES, JF ;
DUBOIS, RE ;
CUNNINGHAMRUNDLES, C ;
PAHWA, S ;
TOSATO, G ;
ZEGANS, LS ;
PURTILO, DT ;
BROWN, N ;
SCHOOLEY, RT ;
BRUS, I .
ANNALS OF INTERNAL MEDICINE, 1988, 108 (03) :387-389
[6]  
Howell DC, 2013, Statistical methods for psychology
[7]   FATTY-ACIDS IN PLASMA AND RED-CELL MEMBRANES IN NORMAL HUMANS [J].
MANKU, MS ;
HORROBIN, DF ;
HUANG, YS ;
MORSE, N .
LIPIDS, 1983, 18 (12) :906-908
[8]  
*ROYAL COLL PHYS P, 1996, CHRON FAT SYNDR
[9]   FOLLOW-UP OF PATIENTS PRESENTING WITH FATIGUE TO AN INFECTIOUS-DISEASES CLINIC [J].
SHARPE, M ;
HAWTON, K ;
SEAGROATT, V ;
PASVOL, G .
BRITISH MEDICAL JOURNAL, 1992, 305 (6846) :147-152
[10]   A REPORT-CHRONIC FATIGUE SYNDROME - GUIDELINES FOR RESEARCH [J].
SHARPE, MC .
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1991, 84 (02) :118-121