Activation of recombinant human SK4 channels by metal cations

被引：20

作者：

Cao, YJ ^{[1
]}

Houamed, KM ^{[1
]}

机构：

[1] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA

来源：

FEBS LETTERS | 1999年 / 446卷 / 01期

关键词：

potassium channel; calcium; divalent metal; calmodulin;

D O I：

10.1016/S0014-5793(99)00194-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of metal cations on the activation of recombinant human SK4 (also known as hIK1 or hKCa4) channels, expressed in HEK 293 cells, were tested using patch clamp recording. Of the nine metals tested, cobalt, iron, magnesium, and zinc did not activate the SK4 channels when applied, at concentrations up to 100 mu M, to the inside of SK4 channel-expressing membrane patches. Barium, cadmium, calcium, lead, and strontium activated SK4 channels in a concentration-dependent manner. The rank order of potency was at Ca2+ > Pb2+ > Cd2+ > Sr2+ > Ba2+. (C) 1999 Federation of European Biochemical Societies.

引用

页码：137 / 141

页数：5

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