Cannabinoid receptors and the regulation of immune response

被引：221

作者：

Berdyshev, EV ^{[1
]}

机构：

[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2000年 / 108卷 / 1-2期

关键词：

cannabinoids; cannabinoid receptors; tetrahydrocannabinol; anandamide; N-acylethanolamines; immune response;

D O I：

10.1016/S0009-3084(00)00195-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cannabinoid research underwent a tremendous increase during the last 10 years. This progress was made possible by the discovery of cannabinoid receptors and the endogenous ligands for these receptors. Cannabinoid research is developing in two major directions: neurobehavioral properties of cannabinoids and the impact of cannabinoids on the immune system. Recent studies characterized the cannabinoid-induced response as a very complex process because of the involvement of multiple signalling pathways linked to cannabinoid receptors or effects elicited by cannabinoids without receptor participation. The objective of this review is to present this complexity as it applies to immune response. The functional properties of cannabinoid receptors, signalling pathways linked to cannabinoid receptors and the modulation of immune response by cannabinoid receptor ligands are discussed. Special attention is given to 'endocannabinoids' as immunomodulatory molecules. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：169 / 190

页数：22

共 160 条

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