Acetylcholine recognition by a deep, biomimetic pocket

被引：88

作者：

Hof, F

Trembleau, L

Ullrich, EC

Rebek, J

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 27期

关键词：

acetylcholine; cation-pi interactions; host-guest systems; molecular recognition; receptors;

D O I：

10.1002/anie.200351174

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four negative charges at the entrance of a deep pocket, lined with aromatic residues are the features of a synthetic receptor which shows high affinity for acetylcholine (see picture) and choline in water. The size, shape, and charge recognition elements featured in the natural enzyme acetylcholinesterase are reproduced by the synthetic receptor.

引用

收藏

页码：3150 / 3153

页数：4

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